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Metenolone enanthate, or methenolone enanthate, is a dihydrotestosterone (DHT)-based anabolic steroid. It is an ester derivative of methenolone sold commonly under the brand names Primobolan (tablet form) or Primobolan Depot (injectable). When it interacts with the aromatase enzyme it does not form any estrogens.[medical citation needed] It is used by people who are very susceptible to estrogenic side effects, having lower estrogenic properties than nandrolone. Methenolone, in form of enanthate and acetate, is available as an injection or as an oral formulation. The injection is regarded as having a higher bioavailability. It is an enanthate ester which is quite long-acting. Because it by-passes hepatic breakdown on the first pass, it also has a higher survival rate. The tablets are in a short-lived acetate form. Methenolone is not 17-alpha-alkylated, but 1-methylated for oral bioavailability. This reduces the stress on the liver, but also the availability. In doses of 200 mg per week or less (intramuscular) blood pressure is rarely altered.
Side effects in general are usually not much of a problem with Primobolan Depot. There is a chance to notice a few residual androgenic effects such as oily skin, acne, increased facial/body hair growth or an aggravation of male pattern baldness condition. This steroid is still very mild however, and such problems are typically dose related. Women will in fact find this preparation mild enough to use in most cases, observing it to be a very comfortable and effective anabolic. If both the oral and injectable were available for purchase, the faster acting oral should probably be given preference however.
This is simply due to the fact that blood hormone levels are more difficult to control with a slow acting injectable, the user also having to wait many days for steroid levels to diminish if side effects become noticeable. Overall, Primobolan Depot is actually considered to be one of the safest anabolic steroids available. Steroid novices, older athletes or those sensitive to side effects would undoubtedly find it a very favorable drug to use. The typical "safe" dosage for men is 100-200mg per week, a level that should produce at least some noticeable muscle growth.
In European medicine it is not uncommon for Primobolan to be used safely at such a dosage for extended periods of time. Among athletes, men may respond to weekly doses of 200mg but regular users will often inject much higher doses looking for a stronger anabolic effect. It is not uncommon for a bodybuilder to take as much as 600 or 800mg per week (6 to 8 100mg ampules), a range which appears to be actually quite productive. Of course androgenic side effects may become more pronounced with such an amount, but in most instances it should still be quite tolerable.
Methenolone can be suppressive of the hypothalamic-pituitary-gonadal axis.